Airo national research journal


Consideration of Diversity



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Consideration of Diversity


The United States has traditionally been known as a melting pot, as the nation has accepted and encouraged diversity throughout its history. If you grew up in an area that is not particularly diverse, you may find it difficult to adjust to people from different cultures or with different values whom you meet in the working world or in higher education. Engaging in team sports can help you develop meaningful friendships and foster understanding among a diverse range of people.

Evaluated Performances


Playing sports can help you put you to establish solid core values. According to the parenting website Families.com, children who play sports are less likely to smoke or use drugs, and girls who play sports are less likely to become pregnant. Those who play sports in high school may also have better academic success.

Developed Thinking


Thinking critically and making quick decisions that will further your team's strategy are necessary for success at higher levels of sports competition. The logical consideration and critical thinking that you engage in to help your team claim victory can cross over to many other areas of your life and may help promote improved performance on college entrance exams and higher education activities.

Physical Strength


Sports also help bring out a diverse range of physical abilities, but they vary widely depending on your chosen activity. Sports such as football and hockey can bring out physical strength and speed; soccer and volleyball can improve agility; and basketball and distance running can foster endurance. Sports may also help develop physical abilities such as a high vertical leap, hand-eye coordination and balance.

References

AYW Sports Reports Volume III

www.jinglesports.com

LNIPU Physical Sports Reviews 2010.

 

Study of Gene therapy

Submitted by Neera Gupta

Introduction

Following early advances in genetic engineering of bacteria, cells and small animals, scientists started considering how to apply it to medicine. Two main approaches were considered – replacing or disrupting defective genes. Scientists focused on diseases caused by single-gene defects, such as cystic fibrosis, haemophilia, muscular dystrophy,thalassemia and sickle cell anemia. Glybera treats one such disease, caused by a defect in lipoprotein lipase.



Reviews

In 1992 Claudio Bordignon, working at the Vita-Salute San Raffaele University, performed the first gene therapy procedure using hematopoietic stem cells as vectors to deliver genes intended to correct hereditary diseases  In 2002 this work led to the publication of the first successful gene therapy treatment for adenosine deaminase-deficiency (SCID). The success of a multi-center trial for treating children with SCID (severe combined immune deficiency or "bubble boy" disease) from 2000 and 2002, was questioned when two of the ten children treated at the trial's Paris center developed a leukemia-like condition. Clinical trials were halted temporarily in 2002, but resumed after regulatory review of the protocol in the US, the United Kingdom, France, Italy and Germany.[47]

In 1993 Andrew Gobea was born with SCID following prenatal genetic screening. Blood was removed from his mother'splacenta and umbilical cord immediately after birth, to acquire stem cells. The allele that codes for adenosine deaminase (ADA) was obtained and inserted into a retrovirus. Retroviruses and stem cells were mixed, after which the viruses inserted the gene into the stem cell chromosomes. Stem cells containing the working ADA gene were injected into Andrew's blood. Injections of the ADA enzyme were also given weekly. For four years T cells (white blood cells), produced by stem cells, made ADA enzymes using the ADA gene. After four years more treatment was needed. Jesse Gelsinger's death in 1999 impeded gene therapy research in the US.[48][49] As a result, the FDA suspended several clinical trials pending the reevaluation of ethical and procedural practices

 

DNA must be administered, reach the damaged cells, enter the cell and express/disrupt a protein. Multiple delivery techniques have been explored. The initial approach incorporated DNA into an engineered virus to deliver the DNA into a chromosome. Naked DNA approaches have also been explored, especially in the context of vaccinedevelopment.



Generally, efforts focused on administering a gene that causes a needed protein to be expressed. More recently, increased understanding of nuclease function has led to more direct DNA editing, using techniques such as zinc finger nucleases and CRISPR. The vector incorporates genes into chromosomes. The expressed nucleases then "edit" the chromosome. As of 2014 these approaches involve removing cells from patients, editing a chromosome and returning the transformed cells to patients.

Other technologies employ antisense, small interfering RNA and other DNA. To the extent that these technologies do not alter DNA, but instead directly interact with molecules such as RNA, they are not considered "gene therapy" per se



Importance

Genes that are flawed and do not work properly can cause disease. Gene therapy is a technique for correcting defective genes responsible for disease development. Researchers may use one of several approaches for correcting faulty genes:



  • A normal gene may be inserted into a nonspecific location within the genome to replace a nonfunctional gene. This approach is most common.

  • An abnormal gene could be swapped for a normal gene through homologous recombination.

  • The abnormal gene could be repaired through selective reverse mutation, which returns the gene to its normal function.

  • The regulation (the degree to which a gene is turned on or off) of a particular gene could be altered.

References

http://cisncancer.org/research/new_treatments/gene_therapy/importance.html

www.wikipedia.com

 

 



Effectiveness of Physical Growth Urban College’ Students

Submitted by: Ratan Kumar Physical Education

 

General Facts

The ignorance towards physical fitness of the players has caused so many failures in the international level competitions.
The main aim of this study is to explore the reasons of lower level of fitness, to improve the same, to acquaint the players and the coaches about their fitness level, so that they can improve their present level and make good performance in the Olympics.

This investigation aims on testing their levels of fitness so that proper schedule can be prepared by taking the results of this study as reference.

Study can also help in selecting the best players on the basis of the knowledge of their fitness.
Thus by testing the fitness level of the players, they can be provided with good diet, psychological support, special and scientific training, specialized and other necessaries according to their need so the importance of this investigation is clear.

Hypotheses of the study are:

1) There will be no significant difference in the score of the flex arm  hang (arm shoulder strength) of forward and defence line women hockey players.
2)   There will be a significant differences in the sit-ups (abdominal strength) of forward and defence line women hockey players.

3) There will be no significant difference in standing broad jump (power of leg muscles) of forward and defence line women hockey players.

4) There will be a significant difference in the scores of shuttle-run (agility) of forward and defence line women hockey players.

5) There will be a significant difference in the 50 yards (speed) of of forward and defence line women hockey players.


6)  There exists a significant difference in 1milerun/walk(endurance) of forward and defence line women hockey players.

DELIMITATIONS


1.   The study is confined to the women hockey players of Amritsar and Jalandhar districts of Punjab, India.
2.   The study is delimited on 50 women hockey players between the age group of 18-25 years.
3.     Life style and habits of the player are not taken into consideration.
4.   AAPHER physical fitness test battery is used to collect the raw score, which is considered as the delimitation of the study.

LIMITATIONS

1     No special motivational techniques are used to boost
       the subjects to perform during test.

2     Ground conditions at the time of the test were not of


       the standard conditions.

3           Efforts from subjects, may not be their best performance while performing in the test, which is also one of the limitation of the study.

4     Climatic conditions varied at different days at the time of the test.

5     Some players are not fully fit, which is also considered as the limitation of the study.

6     All the subjects were not available at one time for conducting the physical; fitness test.

References:

 


  • www.worldsports/i29/webers

  • Chade, Anna Espens, “Fitness of Fourth Grade Children” Research Quarterly 29 (Oct 1958) : 274

  • Clarke, H. Harrison. “The Physical Fitness Values” SNIPES Journal 1 (Jan. 1981) : 60

  • www.sportsmania.com

 

 

 AIRO RESEARCH JOURNALS



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Email; airo@airo.co.in

www.airo.co.in





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