Supplemental Material Carbohydrate utilization

B. Pili

Gene	H. somnus 129Pt	H. ducreyi 35000HP	H. influenzae Rd
Possible competence, pili, secretion system genes in H. somnus 129Pt
Competence
comA competence protein A	HS_1109	HD0427	HI0439
comB competence protein B	HS_1110	no	HI0438
comC competence protein C	HS_1111	HD0432	HI0437
comD competence protein D	no	no	HI0436
comE competence protein E	HS_1112	HD0434	HI0435
Type 4 pili
pilA pilin	HS_0250	HD1123	HI0299
pilB nucleotide binding protein	HS_1430	HD1124	HI0298
pilC inner membrane protein	HS_0457	HD1125	HI0297
pilD prepilin peptidase and methylase	HS_0458	HD1126	HI0296
pilM domains in common with cell division protein FtsA and rod-shape-determining protein MreB	no	no	no
pilN cytoplasmic membrane protein	no	no	no
pilO cytoplasmic membrane protein	no	no	no
pilP possible lipoprotein	no	no	no
pilQ outer membrane protein secretin – pilus extrudes through this	no	no	no
pilT motor required for motility	no	no	no
minor pilin-like proteins
pilE	no	no	no
pilV	no	no	no
pilW	no	no	no
pilX	no	no	no
fimT (not essential)	no	no	no
fimU	no	no	no
H. influenzae type b pilus
hifA	no	no	no
hifY3	no	no	no
hifY1	no	no	no
hifY2	no	no	no
hifB	no	no	no
hifC	no	no	no
hifD	no	no	no
hifE	no	no	no
E. coli type 1 pilus
fimA	no	HD0281 38% aa identity	no
fimB	no	no	no
fimH	no	no	no
fimC	no	HD0284 32% aa identity	no
fimD	no	HD0283 28% aa identity	no