Richard paschal cochran, M. D. Personal data



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Curriculum Vitae


RICHARD PASCHAL COCHRAN, M.D.


PERSONAL DATA
Office Address: Home Address:

Maui Memorial Medical Center 708 Noweo Place

221 Mahalani St Wailuku, HI 96793

Wailuku, HI 96793


Office Contacts: Home Contacts:

(808) 242-2680 office (808) 214-6168

(808) 214-2691 cell

rcochran@hhsc.org e-mail
Birthdate and Place:

January 9, 1952

Anderson, South Carolina

EDUCATION
College:
1970-1974 B.S., Premed

Davidson College; Davidson, North Carolina


Medical School:
1974-1978 M.D.

Emory University School of Medicine; Atlanta, Georgia



Post Graduate Training:

1985-1986 Chief Resident

Cardiovascular and Thoracic Surgery

University of Utah; Salt Lake City, Utah




    1. Resident

Cardiovascular and Thoracic Surgery

University of Utah; Salt Lake City, Utah


1983-1984 Chief Resident

General Surgery

University of Texas Health Science Center; Dallas, Texas

1981-1982 Surgical Research Fellowship

Transplant Immunology

University of Texas Health Science Center; Dallas, Texas
1979-1983 General Surgery Residency

University of Texas Health Science Center; Dallas, Texas


1978-1979 Internship, General Surgery

University of Texas Health Science Center; Dallas, Texas



POSITIONS HELD
2008-present Director of Cardiovascular and Thoracic Surgery

Maui Memorial Medical Center

Wailuku, Hawaii
2002-2008 Medical Director of Cardiac Surgery

Central Maine Heart and Vascular Institute

Central Maine Medical Center, Lewiston, Maine
2006- present Graduate Faculty, Mechanical Engineering

University of Maine, Orono, Maine


2007- present Vice-President

Superior Surgical Solutions

Auburn, Maine
1998-2002 Professor and Chair

Division of Cardiothoracic Surgery

University of Wisconsin; Madison, Wisconsin
1995-1998 Associate Professor

Division of Cardiothoracic Surgery

University of Washington; Seattle, Washington
1990-1995 Assistant Professor

Division of Cardiothoracic Surgery

University of Washington; Seattle, Washington
1986-1990 Assistant Professor

Division of Thoracic and Cardiovascular Surgery

University of Texas Southwestern Medical School; Dallas, Texas
1981-1984 Instructor, Surgery

Physicians’ Assistant Program

University of Texas Health Science Center; Dallas, Texas

HOSPITAL POSITIONS HELD

2008-present Maui Memorial Medical Center


2002-2008 Central Maine Medical Center, Lewiston, Maine

1998-2002 University of Wisconsin Hospital and Clinics, Madison, Wisconsin


1998-2002 William S. Middleton Memorial Veterans Affairs Hospital,

Madison, Wisconsin





    1. University of Washington Medical Center, Seattle, Washington




    1. Harborview Medical Center, Seattle, Washington




    1. Veterans Affairs Hospital, Seattle, Washington




    1. Chief, Cardiothoracic Surgery

Veterans Affairs Medical Center, Seattle, Washington


    1. Children’s Medical Center of Dallas, Dallas, Texas




    1. St. Paul Medical Center, Dallas, Texas




    1. Parkland Memorial Hospital, Dallas, Texas

1986-1990 Medical Director, Cardiovascular and Thoracic Intensive Care Unit

Parkland Hospital; Dallas, Texas


    1. Veterans Administration Medical Center; Dallas, Texas


BOARD CERTIFICATIONS
1979 FLEX

1985 American Board of Surgery – #30633


1994 American Board of Surgery Recertification
2002 American Board of Surgery Recertification (exp 07/2015)
1987 American Board of Thoracic Surgery – #4493
1996 American Board of Thoracic Surgery Recertification
1996 American Board of Thoracic Surgery Recertification (exp 12/2107)

  1. Surgical Critical Care, American Board of Surgery – # 1507

2004 Surgical Critical Care, American Board of Surgery (exp 10/2017)

CURRENT LICENSES TO PRACTICE
Maine #016119 Valid since 11/01/02 Expires 01/31/12

Hawaii #MD-13921 Valid since 08/01/02 Expires 01/31/10

Wisconsin #40092 Valid since 08/28/98 Expires 10/31/11

Washington #27949 Valid since 01/09/90 Expires 01/09/12

Utah #84-172067-1205 Valid since 01/31/84 Expires 01/31/12

Texas #F3849 Valid since 05/31/79 Expires 05/31/11


PROFESSIONAL ORGANIZATIONS
Association for Academic Surgery

American Heart Association

American Society for Artificial Internal Organs

Fellow, American Association of Thoracic Surgeons

Fellow, American College of Chest Physicians

Fellow, American College of Cardiology

Fellow, American College of Surgeons

Henry Harkins Surgical Society

International Association for Cardiac Biological Implants

International Society for Heart and Lung Transplantation

Le Club Mitrale

Pacific Coast Surgical Association

Parkland Surgical Society

Seattle Surgical Society

Society of Critical Care Medicine

Society for Heart Valve Disease

Society of Thoracic Surgeons

Surgeons As Educators

Maine State Medical Association

Western Thoracic Surgical Association



AWARDS
Madison Area’s Best Doctors, Cardiothoracic Surgery, 2000, Madison Magazine

America’s Top Surgeons, Cardiothoracic Surgery, 2004-2005, Consumer Research Council of America


TEACHING RESPONSIBILITIES
1993-1998 Chairman, Cardiothoracic Division Education Committee, University of Washington–Seattle
• Devise overall educational program for Cardiothoracic Residents,

General Surgery Residents, Externs, and PA students


1993-1998 Director, Core Curriculum for Cardiothoracic Surgery Residency, University of Washington–Seattle
• Weekly Teaching Rounds - General Surgery residents and externs
• Wednesday Cath Conference and Grand Rounds
• Saturday Conference (Didactic Lectures, Current Journal Club,
Selected Readings)
1994-1998 Co-Director, Biomedical Engineering Journal Club, University of Washington–Seattle
1994-2002 Editor, Selected Readings in Cardiothoracic Surgery “Classics in Cardio-Thoracic Surgery”

Student Mentorship
Medical Students–Primary Mentor


  1. Ann Branchaud, M.D., School of Medicine, University of Washington–Seattle, Advisor, Medical Student Research: Cardiac Surgery in Octogenarians, 8/95-3/98.

  2. Wendy Norris, M.D., School of Medicine, University of Washington–Seattle, Advisor, Medical Student Research: Replacement of Pharmacologic Potassium Supplement with Potassium-Rich Substitutes, 6/95-3/98.

Doctoral Students–Supervisory Committee Member

  1. Karyn S. Kunzelman, Ph.D., Doctoral Degree in Biomedical Engineering, University of Texas Southwestern Medical Center–Dallas, Dissertation Title: Engineering Analysis of Mitral Valve Structure and Function, 8/86-4/91.

  2. Jane Grande, Ph.D., Doctoral Degree in Bioengineering, University of Washington– Seattle, Dissertation Title: The Aortic Root–Aortic Valve Relationship in the Normal, Diseased, and Surgically Repaired States, 10/91-4/98.

  3. David Quick, B.S., Doctoral Degree in Bioengineering, University of Wisconsin– Madison, Dissertation Research: Mitral Valve Remodeling, 9/98-5/01.

  4. Dan Einstein, B.S., Doctoral Degree in Bioengineering, University of Washington– Seattle, Thesis Research: Modal Analysis of Heart Sounds, 1/97-11/02.

Master’s Students–Committee Member

  1. Matthew Reimink, Master’s Degree in Bioengineering, University of Washington–Seattle, Thesis Title: Evaluation of Mitral Valve Ring Annuloplasty, 10/93-6/96.

  2. David Quick, B.S., Master’s Degree in Mechanical Engineering, University of Washington–Seattle, Thesis Title: Mitral Valve Response to Cardiac Ischemia Induced Stress Changes: Implications to Valve Repair and Replacement Design, 1/95-5/98.

  3. Adam Berman, B.S., Master’s Degree in Mechanical Engineering, University of Washington– Seattle, Thesis Research: Stress Patterns in Thoracic Aneurysms–A Finite Element Model, 10/96-10/98.

  4. Mario Tapia, B.S., Master’s Program, Mechanical Engineering, University of Washington–Seattle, Thesis Research: Combined Mechanical and Fluid Modeling of the Mitral Valve: 11/96-12/99.

  5. Jeff Kasalko, M.S., Master’s Degree in Biomedical Engineering, University of Wisconsin–Madison, Thesis Research: The Biaxial Properties of Porcine Ascending Aortic Wall Tissue, 10/98-5/01.

  6. Laura Kranendonk, M.S., Master’s Degree in Biomedical Engineering, University of Wisconsin–Madison, Thesis Research: Effect of Shear Stress and Binding Substrate on Endothelial Cell Adhesion, 9/99-5/01.

  7. Kelley Dwyer, B.S., Master’s Degree in Biomedical Engineering, University of Wisconsin–Madison, Thesis Research: Regurgitation Dependent Collagen Concentration in Ovine Mitral Valves, 9/99-8/01.

  8. Kristina Jensen, B.S., Master’s Program, Biomedical Engineering, University of Wisconsin–Madison, Thesis Research: Quantitative Histologic Analysis of Mitral Valve Tissue, 1/00-6/02.

  9. Talya Reilly, B.S., Master’s Program, Biomedical Engineering, University of Wisconsin–Madison, Thesis Research: Biaxial Properties of Photofixed Pericardium, 8/01-8/02.

Additional Educational Responsibilities

1991-1998 Co-Director, Division of Cardiothoracic Surgery Continuing Medical Education, University of Washington–Seattle


Annual Visiting Scholar Program and Research Forum
Tirone David, M.D., “The Stentless Porcine Valve, A Realistic Alternative?” May 1992
Hermes Grillo, M.D., “Neoplasms of and in the Airway,” May 1993
Andrew Wechsler, M.D., “Revascularization for Ischemic Cardiomyopathy: The Dilemma of Mitral Regurgitation,” May 1994
Hillel Laks, M.D., “Unifocalization and Definitive Repair for Pulmonary Atresia with Multiple Aorta to Pulmonary Collaterals,” May 1995
James L. Cox, M.D., “Evolution of the Relationship between Cardiologist and Cardiac Surgeons,” May 1996
D. Craig Miller, M.D., “Endovascular Stent/Graft Repair for Patients with Descending Thoracic Aortic Aneurysms–Mid-Term Results of a Grand Clinical Experiment,” May 1997
Mark B. Orringer, M.D., “Modern Concepts in the Treatment of Esophageal Perforation,” May 1998
Educational Forums
Patrick Perrier, M.D., Albert Krause, M.D., “Comparison of the European and U.S. Experiences with the New Carpentier-Edwards Pericardial Valve,” November 1991
Thomas Salerno, M.D., “Myocardial Protection: Retrograde Continuous Warm Blood Cardioplegia,” February 1992
“Risk Stratification in Cardiac Surgery”–Washington and Oregon CT Surgeons, December 1992.
Carlos Duran, M.D., “Cardiac Valve Reconstruction,” November 1993
Manuel J. Antunes, M.D., “Mitral Valve Surgery,” April 1993
Invited speakers, “The Mitral Valve: Concepts and Controversies,” August 1996

SPECIAL NATIONAL RESPONSIBILITIES
1994-1998 Chairman, American Heart Association (Washington Chapter) Committee for Establishment of Guidelines in “Indications for Valvular Heart Surgery”
1996-2002 Membership Committee, Western Thoracic Surgical Association


SPECIAL LOCAL RESPONSIBILITIES
University of Washington Medical Center
1992-1998 Quality Assurance Committee

1992-1998 Cardiac Effectiveness Group

1993-1995 Early Extubation Task Force

1996-1997 Operations Improvement in the Surgical Specialties Center, Steering Committee, and Track Care Task Force

1997-1998 Transfusion Practices Committee

1996-1998 Cardiovascular Services Committee



    1. Surgeon Implant Evaluation Committee


University of Washington Department of Surgery
Chairman, Departmental Quality Assurance Committee
University of Wisconsin
1998-2002 Surgical Education Committee

1998-2002 Surgery Executive Council




RESEARCH FUNDING
Peer Reviewed Funding


  1. Principal Investigator, Improved Thromboresistance for Circulatory Assist Devices, American Heart Association, Texas Affiliate, 7/1/86-6/30/88, $49,903.

  2. Principal Investigator, Noninvasive Evaluation of Cardiac Transplantation, University of Texas Health Science Center, Institutional Grant, 9/1/86-8/31/87, $6,000.

  3. Consultant, Protection from Air Embolism with Perfluorocarbons in Cardiopulmonary Bypass, American Society for Extracorporeal Technology, 1/1/93-12/31/93, $11,000 (Bruce Spiess, PI).

  4. Co-Investigator, Biomechanical Determinants of Aortic Valve Function, Whitaker Foundation, 9/1/94-12/31/96, $119,171 (KS Kunzelman, PI).

  5. Co-Investigator, Effects of Fluid Dynamics and Surgical Alterations on Mitral Valve Function in a Computer Model, American Heart Association, Washington Affiliate, 7/1/95-6/30/97, $62,344 (KS Kunzelman, PI).

  6. Consultant, Effect of Shear Stress on Cellular/Material Interactions; Flow Cell Model Development and Expansion, National Science Foundation, 10/1/96-6/30/01, $309,487. (Part of an Engineering Research Center Grant: University of Washington Engineered Biomaterials), (KS Kunzelman, PI).

  7. Co-Investigator, Biomechanical Determinants of Aortic Valve Function, San Diego Supercomputer Center, 4/1/97-3/31/98, 625 Service Units, (KS Kunzelman, PI).

  8. Principal Investigator, Mitral Valve Regurgitation Induces Structural Changes, National Institutes of Health RO1, Heart Lung and Blood Institute, 7/1/97-6/30/01, $1,244,702.

  9. Co-Investigator, Biomechanical Determinants of Aortic and Mitral Valve Function, San Diego Supercomputer Center, 4/1/98-3/31/99, 4000 Service Units, (KS Kunzelman, PI).

  10. Co-Investigator, T-tubules and L-type Ca2+ Channels in Heart Failure, National Institutes of Health, 7/1/99-6/30/04, $1,807,354, (M Wolf, PI).

  11. Co-Investigator, Effect of Endothelial Cell Integrin Engagement on Protection from Apoptosis Under Conditions of Shear Stress, American Heart Association Northland Affiliate, 7/1/99-6/30/02, $90,000, (KS Kunzelman, PI).

  12. Principal Investigator, Coupled Fluid/Structure Analysis of Aortic Valve Function, Department of Surgery Grant, University of Wisconsin-Madison, 4/1/00-10/31/01, $47,643.

  13. Co-Investigator, Translational Program in Cardiovascular Science, National Institutes of Health, Training Grant, 7/1/01-6/30/06, $1,321,130, (R Moss, PI)

  14. Principal Investigator, Prevention and/or Correction of Ischemic Mitral Regurgitation, UW Medical Foundation, 10/1/01-9/30/02, $68,017.

  15. Principal Investigator, Mitral Valve Repair with the Zeus Surgical Robotics System, UW Medical Foundation, 10/1/01-9/30/02, $44,869.

  16. Co-Investigator, Aortic Valve and Root Evaluation – Model Development and Validation, UW Medical Foundation, 10/1/01-9/30/02, $175,358, (KS Kunzelman, PI).

  17. Sub-contractor, Rapidly Exchangeable Bioprosthetic Heart Valve, National Institutes of Health SBIR grant, 1/1/03-12/31/03, $212,063 (I Vesely, PI).

  18. Co-Investigator, Aortic Valve and Root Function: A Coupled Fluid-Structure Model, American Heart Association, 1/1/03-12/30/04, $130,000, (KS Kunzelman, PI)

  19. Sub-contractor, Biocompatibility of Rapidly Exchangealble Heart Valve, National Institutes of Health SBIR grant, 9/1/03-12/31/03, $212,063 (I Vesely, PI).

  20. Co-Investigator, Percutaneous Mitral Valve Repair: A Validated Fluid-Structure Interaction Model, National Institutes of Health RO1, 8/1/09-6/30/14, $2,995,516, (KS Kunzelman, PI).

Other Funding

  1. Co-Investigator, Evaluation of Perfluorocarbon Emulsion Use in Cardiopulmonary Bypass, Hemagen, Inc., 12/1/92-11/30/94, $32,000 (Bruce Spiess, PI).

  2. Principal Investigator, Randomized Clinical Trial of Large Diameter Vascular Grafts, CarboMedics, Inc., 8/1/93-12/31/95, $23,070.

  3. Co-Investigator, Evaluation of Perfluorocarbons in Protection from Cerebral Air Embolism, Hemagen, Inc., 1/1/94-12/31/95, $240,000 (Bruce Spiess, PI).

  4. Co-Investigator, Toronto Stentless Porcine Valve Clinical Investigation, St. Jude Medical Inc., 6/1/94-12/31/97, $100,000 (Edward D. Verrier, PI).

  5. Principal Investigator, Echocardiographic Evaluation of St. Jude Valves, St. Jude Medical Inc., 6/1/94-12/31/96, $15,500.

  6. Co-Investigator, Evaluation of Aortic Compliance after Implantation of Toronto Stentless Porcine Valves, St. Jude Medical, Inc., 7/1/96-6/30/98, $69,772 (KS Kunzelman, PI).

  7. Principal Investigator, Randomized Trial of Complement Inhibition during Cardiopulmonary Bypass, Alexion Pharmaceutical, 1/1/01-12/31/02.

  8. Principal Investigator, Robotic Mammary Takedown Clinical Trial, Computer Motion, 5/1/02-4/30/02, $75,000.

  9. Principal Investigator, Aortic Valve Operative Outcomes in Marfan Patients Study, 1/1/06-12/31/07, $20,000.

BIBLIOGRAPHY




ARTICLES IN REFEREED JOURNALS

(** Indicates that first author was a graduate student or resident under my direct supervision)




  1. Cochran RP, McGough EC. Bovine pericardium: A source of pulmonary venous obstruction in the mustard procedure. Ann Thor Surg. 1987;44:552-553.

  2. Rosenfeld J, Cochran RP, Abraham M, Hillis LD, Taylor AL. False inferior pseudoaneurysm: 2D and Doppler echocardiographic findings. J Amer Soc of Echocardiogr. 1988;1:351-353.

  3. Cochran RP, Kunzelman KS. Cryopreservation does not alter antigenic expression of aortic allografts. J Surg Res. 1989;46:597-599.

  4. Goff DR, Purdue GF, Cochran RP, Hunt JL. Cardiac disease and the burn patient. J Burn Care and Rehabil. 1990;11:305-307.

  5. **Kunzelman KS, Cochran RP. Mechanical properties of basal and marginal mitral valve chordae tendineae. ASAIO Transactions. 1990;36:M405-M408.

  6. Landreneau RJ, Horton JW, Cochran RP. Splanchnic blood flow response to intra-aortic balloon pump assist of hemorrhagic shock. J Surg Res. 1991;51:281-287.

  7. Cochran RP, Kunzelman KS. Comparison of the viscoelastic properties of suture vs. porcine mitral valve chordae tendineae. J Card Surg. 1991;6:508-513.

  8. Cochran RP, Kunzelman KS, Chuong CJ, Sacks MS, Eberhart RC. Non-destructive analysis of mitral valve collagen fiber orientation. ASAIO Transactions. 1991;37:M447-M448.

  9. Cochran RP, Horton JW, Landreneau RJ, Verrier ED. Myocardial blood flow alterations in response to intra-aortic balloon counterpulsation in a canine hemorrhagic shock model. Surg Forum. 1991;XLII:290-292.

  10. Whitten CW, Latson TW, Cochran RP, Elmore JC, Griffin JD. ST segment elevation during cardiac electrophysiologic surgery. Anesthesiology. 1991;75:161-163.

  11. Kunzelman KS, Cochran RP. Stress/strain characteristics of porcine mitral valve tissue: parallel vs. perpendicular collagen orientation. J Card Surg. 1992;7:71-78.

  12. Kunzelman KS, Cochran RP, Murphree SS, Ring WS, Verrier ED, Eberhart RC. Differential collagen structure in the mitral valve and its relation to biomechanical behavior. J Heart Valve Dis. 1993;2: 236-244.

  13. Kunzelman KS, Cochran RP, Chuong CJ, Ring WS, Verrier ED, Eberhart RC. Finite element analysis of mitral valve pathology. J Long Term Eff Med Implants. 1993;3:161-179.

  14. Kunzelman KS, Cochran RP, Chuong CJ, Ring WS, Verrier ED, Eberhart RC. Finite element analysis of the mitral valve. J Heart Valve Dis. 1993;2:326-340.

  15. Grande KJ, Kunzelman KS, Cochran RP, David TE, Verrier ED. Porcine aortic leaflet arrangement may contribute to clinical xenograft failure. ASAIO J. 1993;39:918-922.

  16. Shen I, Kunzelman KS, Vocelka CR, Verrier ED, Cochran RP. Working model for evaluating lung transplant preservation methods. Am Col Surgeons Surg Forum. 1993;XLIV:306-308.

  17. Kunzelman KS, Grande KJ, David TE, Cochran RP, Verrier ED. Aortic valve and root relationships: Impact on surgical repair. J Thor Card Surg. 1994;1:162-170.

  18. Forbes AD, Wood DE, Cochran RP, Munkenbeck F, Schmidt R, Verrier ED. Schwannoma of the left atrium: Diagnostic evaluation and surgical resection. Ann Thor Surg. 1994;57:743-746.

  19. Kunzelman KS, Cochran RP, Verrier ED, Eberhart RC. An anatomic basis for mitral valve modeling. J Heart Valve Dis. 1994;3:491-496.

  20. Vocelka C, Spiess B, Soltow L, Thomas R, Gohra H, Akimoto H, Rothnie C, Kunzelman K, Verrier E, Cochran RP. A perfluorocarbon emulsion prime additive improves the electro-encephalogram and cerebral blood flow at the initiation of cardiopulmonary bypass in swine. J Am Soc ExtraCorp Tech. 1995;27:6-10.

  21. Cochran RP, Kunzelman KS, Eddy AC, Hofer BO, Verrier ED. Modified conduit preparation creates a pseudo-sinus in aortic valve sparing procedure for ascending aortic aneurysm. J Thorac Cardiovasc Surg. 1995;109:1049-1058.

  22. Reimink SM, Kunzelman KS, Verrier ED, Cochran RP. The effect of anterior chordal replacement on mitral valve function and stresses. ASAIO Transactions. 1995;41:M754-M762.

  23. Verrier ED, Wright IH, Cochran RP, Spiess BD. Changes in cardiovascular surgical approaches to achieve early extubation. J Cardiothorac Vasc Anesth. 1995;9(suppl 5):10-15.

  24. Chandler WL, Fitch JCK, Wall MH, Verrier ED, Cochran RP, Soltow LO, Spiess BD. Individual variations in the fibrinolytic response during and after cardiopulmonary bypass. Thromb Haemost. 1995;74:1293-1297.

  25. Kunzelman KS, Reimink MS, Verrier ED, Cochran RP. Replacement of mitral valve posterior chordae tendineae with expanded polytetrafluoroethylene suture: A finite element study. J Card Surg. 1996;11:136-145.

  26. Whitten CW, Allison PM, Latson TW, Ivy R, Burkhardt D, Gulden RH, Cochran RP. Evaluation of laboratory coagulation and lytic parameters resulting from autologous whole blood transfusion during primary aortocoronary artery bypass grafting. J Clinical Anesth. 1996;8:229-235.

  27. Reimink MS, Kunzelman KS, Cochran RP. The effect of chordal replacement suture length on function and stresses in repaired mitral valves: A finite element study. J Heart Valve Dis. 1996;5:365-375.

  28. Spiess BD, Cochran RP. Perfluorocarbon emulsions and cardiopulmonary bypass: A technique for the future. J Cardiothorac Vasc Anesth. 1996;10:83-90.

  29. Cochran RP, Kunzelman KS. Discrepancies between marked dimensions of prosthetic valves and sizers. J Card Surg. 1996;11:318-324.

  30. Every NR, Maynard C, Cochran RP, Martin J, Weaver WD. Characteristics, management, and outcome of patients with acute myocardial infarction treated with bypass surgery. Circ. 1996;94(suppl)II81-II86.

  31. Cochran RP, Kunzelman K, Vocelka C, Soltow L, Thomas R, Akimoto H, Spiess B. Perfluorocarbon emulsion in the cardiopulmonary bypass prime reduces tneurologic injury. Ann Thor Surg. 1997;63:1326-1332.

  32. Quick DW, Kunzelman KS, Kneebone J, Cochran RP. Collagen synthesis is upregulated in sheep mitral valves subject to altered stress. ASAIO J. 1997;43:181-186.

  33. Kunzelman KS, Reimink MS, Cochran RP. Annular dilatation increases stress in the mitral valve and delays coaptation: A finite element computer model. Cardiovasc Surg. 1997;5:427-434.

  34. Van Norman GA, Gernsheimer T, Chandler WL, Cochran RP, Spiess BD. Indicators of fibrinolysis during cardiopulmonary bypass after exogenous antithrombin III administration for acquired antithrombin III deficiency: A case report. J Cardiothorac Vasc Anesth. 1997;11:760-763.

  35. Herren JI, Kunzelman KS, Vocelka CR, Cochran RP, Spiess BD. Horseradish peroxidase as a histologic indicator of mechanisms of retinal vascular damage and protection with perfluorocarbons following massive air embolism. Stroke. 1997;28:2025-2030.

  36. Kunzelman KS, Reimink MS, Cochran RP. Flexible versus rigid ring annuloplasty for mitral valve annular dilation: A finite element model. J Heart Valve Dis. 1998;7:108-116.

  37. Rand RP, Cochran RP, Aziz SA, Hofer BO, Allen MA, Kunzelman KS, Verrier ED. Prospective trial of catheter irrigation and muscle flaps for sternal wound infections. Ann Thor Surg. 1998;65:1046-1049.

  38. Rosoff JD, Soltow LO, Vocelka CR, Schmer G, Chandler WL, Cochran RP, Kunzelman KS, Spiess BD. A Second generation perfluorocarbon (perfluorodichlorooctane) does not increase complement activation in ex vivo extracorporeal bypass experiments. J Cardiothorac Vasc Anesth. 1998;12:397-401.

  39. Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS. Stress variations in the human aortic root and valve: The role of anatomic asymmetry. Ann Biomed Eng. 1998;26:534-545.

  40. Kunzelman KS, Reimink MS, Cochran RP. Variations in annuloplasty ring and sizer dimensions may alter outcome in mitral valve repair. J Card Surg. 1998;12:322-329.

  41. Herren JI, Kunzelman KS, Vocelka CR, Cochran RP, Spiess BD. Angiographic and histologic evaluation of porcine retinal vascular damage and protection with perfluorocarbons following massive air embolism. Stroke. 1998;21:2396-2403.\

  42. Lee AS, Lawrence O, Scatena M, Giachelli C, Cochran RP, Kunzelman KS. Extracellular matrix proteins enhance the adhesion and NF-kB activation of endothelial cells subjected to shear stress. Am Col Surgeons Surg Forum. 1998;49:294-296.

  43. Spiess BD, Vocelka CR, Cochran RP, Soltow L, Chandler WL. Heparin-coated bypass circuits suppress the release of tissue plasminogen activator during normothermic coronary artery bypass graft surgery. J Cardiothorac Vasc Anesth. 1998;12(3):299-304.

  44. Cochran RP, Kunzelman KS. Effect of papillary muscle position on mitral valve function: relationship to mitral homografts. Ann Thor Surg. 1998;66(Suppl): S155-161.

  45. Kunzelman KS, Quick DW, Cochran RP. Altered collagen concentration in mitral valve leaflets: Biochemical and finite element analysis. Ann Thor Surg. 1998;66(Suppl): S198-205.

  46. Grande KJ, Cochran RP, Reinhall PG, Kunzelman KS. Mechanisms of aortic valve incompetence in aging: a finite element model. J Heart Valve Dis.1999;8(2):149-156.

  47. Davis CL, Kausz AT, Zager RA, Kharasch ED, Cochran RP. Acute renal failure after cardiopulomonary bypass is related to decreased serum ferritin levels. J Am Soc Nephrol. 1999; 10(11):2396-402.

  48. Kunzelman KS, Linker DT, Sai S, Miyake-Hull C, Quick DM, Thomas R, Rothnie C, Cochran RP. Acute mitral valve regurgitation created in sheep using echocardiographic guidance. J Heart Valve Dis, 1999;8(6)637-643.

  49. Quick DW, Kunzelman KS, Cochran RP. Quantitative histologic analysis of the mitral valve anterior leaflet: ischemic alterations and implications for valve replacement designs. In: Farkas DL, Leif RC, Tromberg BJ, eds. Optical Diagnostics of Living Cells. SPIE Vol 3604. Bellingham, WA: SPIE-The International Society for Optical Engineering. 1999;118-128.

  50. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Mechanisms of aortic valve incompetence: A finite element model of aortic root dilatation. Ann Thorac Surg. 2000; 69:1851-7.

  51. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Re-creation of sinuses is important for aortic valve-sparing: A finite element study. J Thor Cardiovasc Surg,2000;119:753-763.

  52. Cochran RP, Kunzelman KS. Methods of pseudo-sinus creation in an aortic valve sparing operation for aneurysmal disease. J Card Surg. 2000;15:428-433.

  53. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Finite element analysis of aortic valve sparing: Influence of graft shape and stiffness. IEEE Trans Biome Eng, 2001:48(6):647-59.

  1. Grande KJ, Cochran RP, Reinhall P, Kunzelman KS. Mechanism of aortic valve incompetence: Finite element modeling of Marfan syndrome. J Thor Cardiovasc Surg, 2001;122:946-954.

  2. Nicosia M, Cochran R, Reinhall P, Einstein D, Kunzelman K. A Coupled fluid-structure model of the aortic valve and root. J Heart Valve Dis, 2003; 12:781-9.

  3. Nicosia M, Kasalko J, Einstein D, Cochran R, Kunzelman K. Biaxial material properties of the porcine aortic wall. J Heart Valve Dis, 2002; 11(5):680-6.

  4. Cochran RP, Starkey TD, Panos AL, Kunzelman KS. Ambulatory intra-aortic balloon pump use as bridge to transplant. Ann Thorac Surg, 2002; 74(3):746-51.

  5. Einstein DR, Reinhall P, Nicosia M, Cochran RP, Kunzelman KS. Dynamic finite element implementation of nonlinear, anisotropic hyperelastic biological membranes. Comp Meth Biomech Biomed Eng, 2003; 6(1):33-44.

  6. Norris W, Kunzelman KS, Bussell S, Rohweder L, Cochran RP. Potassium Supplementation, Diet vs. Pills: A Prospectively Randomized Trial in Post-Operative Cardiac Surgery Patients. Am J Clin Nutrition, 2004; 125:404-9.

  7. Einstein D, Reinhall P, Kunzelman K, Cochran RP: Hemodynamic determinants of the mitral valve closure sound: a finite element study. IEEE Med Biol Eng Comp, 2004; 42(6):832-46.

  8. Quick DW, Kunzelman KS, Hata M, Hegge JO, Rahko PS, Weigel RL, Cochran RP: Effect of infarction and ACE inhibitors on the mitral valve. J Ariz-Nev Acad Sci ,2004; 37(2): 94-99.

  9. Einstein D, Reinhall P, Kunzelman K, Cochran RP: Nonlinear finite element analysis of the mitral valve. J Heart Valve Dis. 2005; (3):376-85.

  10. Einstein D, Reinhall P, Kunzelman K, Cochran RP: The relationship of normal and abnormal microstructural proliferation to the mitral valve closure sound: J Biomech Eng. 2005; 127(1):134-47.

  11. Brown JR, Cochran R, Dacey LJ, Ross CS, Kunzelman KS, Dunton RF, Braxton JH, Charlesworth DC, Clough, RA, Helm RE, Leavitt BJ, MacKenzie TA, O'Connor GT, Perioperative increases in serum creatinine are predictive of increased 90-day mortality following cardiac surgery, Circulation, 2006;114 :I409-I413.

  12. Kunzelman KS, Einstein D, Cochran RP: Fluid structure interaction models of the mitral valve: Function in normal and pathologic states. Philos Trans R Soc Lond B Biol Sci. 2007; 362(1484):1393-406.

  13. Brown JR, Cochran RP, Leavitt BJ, Dacey LJ, Ross CS, MacKenzie TA, Kunzelman KS, Kramer RS, Hernadez F, Helm RE, Westbrook BM, Dunton RF, Malenka DJ, O’Connor GT. Multivariable prediction of renal insufficiency developing after cardiac surgery. Circ 2007;11;116(11 Suppl):I139-43.

  14. Brown JR, Cochran RP, MacKenzie TA, Furnary AP, Kunzelman KS, Ross CS, Langner CW, Charlesworth DC, Leavitt BJ, Dacey LJ, Helm RE, Braxton JH, Clough RA, Dunton RF, O'Connor GT. Long-term survival after cardiac surgery is predicted by estimated glomerular filtration rate. Ann Thorac Surg. 2008;86(1):4-11.

  15. O'Connor GT, Olmstead EM, Nugent WC, Leavitt BJ, Clough RA, Weldner PW, Charlesworth DC, Chaisson K, Sisto D, Nowicki ER, Cochran RP, Malenka DJ Appropriateness of coronary artery bypass graft surgery performed in northern New England. 2008:51(24):2323-8.

  16. Likosky DS, Dacey LJ, Baribeau YR, Leavitt BJ, Clough R, Cochran RP, Quinn R, Sisto DA, Charlesworth DC, Malenka DJ, MacKenzie TA, Olmstead EM, Ross CS, O'Connor GT. Long-term survival of the very elderly undergoing coronary artery bypass grafting Ann Thorac Surg. 2008; 85(4):1233-7.

  17. Schievano S, Kunzelman K, Nicosia M, Cochran R, Khambadkone S, Einstein D, Kunzelman K, Bonhoeffer P: Percutaneous Mitral Valve Dilatation: Single Balloon versus Double Balloon – A Finite Element Analysis. J Heart Valve Dis, 2009;18(1):28-34.

  18. Einstein DR, DelPin F, Jiao X, Kuprat AP, Carson JP, Kunzelman KS, Cochran RP, Guccione JM, Ratclifee MB. Fluid-structure interactions of the mitral valve and left heart: Comprehensive strategies, past, present, and future. Comm Num Meth Eng. Accepted 2009, pre-print available.

  19. Leavitt BJ, Baribeau YR, DiScipio AW, Ross CS, Quinn RD, Olmstead EM, Sisto D, Likosky DS, Cochran RP, Clough RA, Boss RA Jr, Kramer RS, O'Connor GT; Northern New England Cardiovascular Disease Study Group. Outcomes of patients undergoing concomitant aortic and mitral valve surgery in northern New England. Circ 2009; 120(11 Suppl):S127-33.

  20. Likosky DS, Sorensen MJ, Dacey LJ, Baribeau YR, Leavitt BJ, DiScipio AW, Hernandez F Jr, Cochran RP, Quinn R, Helm RE, Charlesworth DC, Clough RA, Malenka DJ, Sisto DA, Sardella G, Olmstead EM, Ross CS, O'Connor GT. Long-term survival of the very elderly undergoing aortic valve surgery. Circulation. 2009; 120(11 Suppl):S155-62

Book Chapters

  1. Cochran RP, Kunzelman KS. Aortic valve sparing in aortic root disease. In: Karp D, Laks H, Wechsler AS, eds. Advances in Cardiac Surgery. Vol. 8. St. Louis, Mo: Mosby-Year Book, Inc.; 1996:81-107.

  2. Kunzelman KS, Cochran RP. Computer models. In: Troidl H, Spitzer WO, McPeek B, Mulder DS, McKneally MF, Wechsler AS, eds. Surgical Research: Basic Principles and Clinical Practice. 3rd ed. New York, NY: Springer-Verlag, Inc.; 1997:453-470.

  3. Kunzelman KS, Cochran RP. Hemi-homograft replacement of the mitral valve: A finite element model. In: Huysmans HA, David TE, Westaby S, eds. Stentless Bioprostheses.2nd ed. Oxford, England: Isis Medical Media, Ltd., 1999:31-38.

  4. Cochran RP, Verrier ED. Valvular heart disease: The surgical approach. In: Otto CM, ed. Valvular Heart Disease. Philadelphia, Pa: Saunders Co. 1999:151-178.

  5. Cochran RP, Kunzelman KS. Valve sparing operations for aortic annulo-ectasia. In: Franco K, Verrier ED, eds., Advanced Therapy in Cardiac Surgery. 1st ed. Hamilton, Ontario, Canada: B.C. Decker Inc 1999:280-291.

  6. Cochran RP, Panos AL. Coronary Artery Bypass Surgery. In: Douglas PS, ed. Women and Heart Disease. Philadelphia, Pa: Saunders Co. 2002:372-382.

  7. Cochran RP, Kunzelman KS. Valve sparing operations for aortic annulo-ectasia. In: Franco K, Verrier ED, eds., Advanced Therapy in Cardiac Surgery. 2nd ed. Hamilton, Ontario, Canada: B.C. Decker Inc 2003:311-322.


Other Publications

  1. **Kunzelman KS, Cochran RP, Chuong CJ, Eberhart RC. Engineering analysis of mitral valve repair. In: Digest of Papers, 6th Southern Biomedical Engineering Conference. 1987:12-13.

  2. **Kunzelman KS, Sacks MS, Cochran RP, Eberhart RC. Mitral valve leaflet collagen distribution by laser analysis. In: Digest of Papers, 7th Southern Biomedical Engineering Conference. 1988;82-85.

  3. **Kunzelman KS, Cochran RP, Eberhart RC. Mechanical properties of mitral valve chordae tendineae. In: Digest of Papers, 7th Southern Biomedical Engineering Conference. 1988:80-81.

  4. Huo HH, Tsai CC, Tunstall A, Cochran RP, Eberhart RC. Albumin affinity and thromboresistance of poly (C16) alkyl sulfone. In: Digest of Papers, 7th Southern Biomedical Engineering Conference. 1988:77-79.

  5. Cochran RP, Mattox KL. Blunt chest injury after horizontal deceleration. Postgraduate General Surgery. 1990;2(3):143-146.

  6. Cochran RP, Rohrich RJ. Repair of sternal dehiscence using a harrington compression system [letter to the editor]. Ann Thorac Surg. 1990;49:853-854.

  7. Cochran RP, Kunzelman KS, Vocelka CR, Akimoto H, Thomas R, Soltow LO, Spiess BD. Macroscopic bubbles from dissolved nitrogen during CPB–Reply. Ann Thor Surg. 1998;54:1527.


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