Bell et al.12 2006
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Fluoxetine treatment and testosterone
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Cohort study
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14 depressed patients treated with fluoxetine, their baseline and 1-month post treatment testosterone and apathy scores compared
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Fluoxetine and apathy questionnaire.
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No change in pre and post treatment for study population as a whole. Large differences within group but cancelling each other out
New apathy instrument developed by authors
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Goodwin et al.13 2017
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Emotional blunting with antidepressant treatment: a survey among depressed patients
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Cross-sectional Internet based survey qualitative study of asking single question “to what extent have you experienced emotional effects of your antidepressant
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669 on treatment and 150 recovered controls who had stopped antidepressants at least 2 months previously
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The question “to what extent have you experienced emotional effects of your antidepressant” and Oxford Questionnaire on emotional side effects
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46% of currently treated patient reported emotional blunting
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7.966 invitations – selection bias of those reporting and currently on antidepressants.
Authors were employees of Servier
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