A review of ssri-induced indifference



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Ven draft 11 july
Gaillard et al.9 2014


Effects of agomelatine compared to escitalopram on motivation

9-week RCT comparing cognitive variables of motivation etc.

133 healthy volunteers with no medical findings

Randomly treated with escitalopram, agomelatine or placebo

Results of probabilistic tasks

No explanation of how probabilistic task is a valid measure of motivation

Health volunteers



Furlan et al.10 2004

SSRIs do not cause affective blunting in healthy elderly volunteers

3-week double-blinded study, volunteers assessed weekly and recorded mood and events in daily diary

Normal health volunteers age range 65-84, SSRI group n=30

Randomly treated with placebo, paroxetine and sertraline for 3 weeks

SSRIs not associated with affective toxicity in elderly persons

Outcome measures not coded with any accuracy


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